CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 36 enrolled
Drug / intervention
Linac Based VMAT TBIradiation
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04509765
NCT04509765N/ACompleted
CompareCT.gov

A Phase II Single-Arm Study of Total Body Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) and Image Guided Radiation Therapy (IGRT)

NYU Langone Health·interventional·Posted Aug 12, 2020·Updated May 4, 2026

In Brief

A clinical study evaluating Linac Based VMAT TBI for Hematologic Malignancy. Completed, enrolled 36 participants across 1 site.

Detailed Summary

Single institution study of safety of linac based VMAT TBI for myeloablative treatment in hematologic malignancies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHematologic Malignancy
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedAug 12, 2020
Enrollment StartSep 22, 2020
Primary CompletionFeb 11, 2025
TodayJul 2, 2026
Enrollment to primary: 4.4 yearsPosted 5.9 years ago

Interventions

Linac Based VMAT TBIradiation

Use of linac based Volumetric Arc Therapy (VMAT) to deliver Total Body Irradiation (TBI). The study intervention is a VMAT based delivery technique using a 6 MV photon beam from a Varian TrueBeam® (Palo Alto, CA) equipped with a Millennium multi-leaf collimation (MLC) system3. TBI will be delivered using a Varian TrueBeam linear accelerator with photon beam VMAT capability. VMAT is a radiation technique combining dynamic photon fluence modulation using multi-leaf collimation (MLC) with gantry rotation to deliver a highly conformal dose distribution with improved target coverage and sparing of organs at risk (OARs).