CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 1,385 enrolled
Drug / intervention
Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg +7 moredrug
Likely dose
Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04518293
NCT04518293Phase 3Completed
CompareCT.gov

Efficacy and Safety of GMRx2 (a Single Pill Combination Containing Telmisartan/Amlodipine/Indapamide) Compared to Dual Combinations for the Treatment of Hypertension

George Medicines PTY Limited·interventional·Posted Aug 19, 2020·Updated Jun 3, 2025

In Brief

A Phase 3 clinical trial evaluating Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mg, telmisartan 40 mg/amlodipine 5 mg/indapamide 2.5 mg, and 6 other interventions for Hypertension. Completed, enrolled 1,385 participants across 89 sites in 7 countries.

Detailed Summary

Recent hypertension guidelines recommend combination therapy as initial treatment for many or most patients. Several trials suggest triple low-dose combination therapy may be highly effective in terms of achieving blood pressure (BP) control without increasing adverse effects. This trial is designed to investigate the efficacy and safety of GMRx2 in participants with high blood pressure compared to dual combinations.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension
CountriesAustralia, Czechia, New Zealand, Poland, Sri Lanka, United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
202120222023202420252026
First PostedAug 19, 2020
Enrollment StartJul 9, 2021
Primary CompletionAug 11, 2023
Study CompletionSep 1, 2023
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 5.9 years ago

Interventions

Telmisartan 20 mg/amlodipine 2.5 mg/indapamide 1.25 mgdrug

Single pill

telmisartan 40 mg/amlodipine 5 mg/indapamide 2.5 mgdrug

Single pill

Telmisartan 20 mg/amlodipine 2.5 mgdrug

oral tablet

telmisartan 40 mg/amlodipine 5 mgdrug

oral tablet

Telmisartan 20 mg/indapamide 1.25 mgdrug

oral tablet

telmisartan 40 mg/indapamide 2.5 mgdrug

oral tablet

Amlodipine 2.5 mg/indapamide 1.25 mgdrug

oral tablet

amlodipine 5 mg/indapamide 2.5 mgdrug

oral tablet