CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 14 enrolled / 14 target
Drug / intervention
Nicotinedrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04521647
NCT04521647Phase 1CompletedUpdate Overdue (0.3/mo)Completion was 35mo ago
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Effects of Menthol in E-cigarettes on Smoking Behaviors

Yale University·interventional·Posted Aug 20, 2020·Updated Jun 16, 2026

In Brief

A Phase 1 clinical trial evaluating Nicotine for Nicotine Dependence. Completed, enrolled 14 participants across 1 site.

Signals

Enrollment appears stalled

Detailed Summary

The overall goal of this proposal is to understand the relationship between nicotine metabolism and menthol flavor in e-cigarettes on smoking behavior in smokers.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNicotine Dependence
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Phase 1CompletedFinished
202120222023202420252026
First PostedAug 20, 2020
Enrollment StartMay 10, 2022
Primary CompletionJul 25, 2023
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 5.9 years ago

Arms & Interventions

5% nicotine with menthol flavor and tobacco flavorexperimental

All participants will receive 5% nicotine/menthol and 5% nicotine/tobacco e-cigarettes over the course of 2 lab sessions; the order of which flavor goes first at each lab session is counterbalanced with half getting menthol flavor first and half getting tobacco flavor first.

Drug: Nicotine

Interventions

Nicotinedrug

Participants will receive 5% nicotine in two flavor exposures via e-cigarettes. Each exposure will be 10 3-sec puffs