CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 60 enrolled
Drug / intervention
Methadone Injectable Productdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04526236
NCT04526236Phase 4Completed
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Influence of Aging on Perioperative Methadone Dosing

Pontificia Universidad Catolica de Chile·interventional·Posted Aug 25, 2020·Updated Dec 21, 2023

In Brief

A Phase 4 clinical trial evaluating Methadone Injectable Product for Pain, Postoperative and 2 related conditions. Completed, enrolled 60 participants across 1 site.

Detailed Summary

Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid for perioperative pain management, however, to date there are no pharmacokinetic or pharmacodynamic studies that asses a methadone dose adjustment in the elderly patient. The present study is aimed to characterize the pharmacokinetic and pharmacodynamic age-related changes of methadone in the adult population and further to design reference dosing protocols for intraoperative methadone use according to patient age.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain, Postoperative, Opioid Use, Methadone Overdose of Undetermined Intent
CountriesChile
Collaborators--

Timeline

Phase 4CompletedFinished
2020202120222023202420252026
First PostedAug 25, 2020
Enrollment StartSep 3, 2019
Primary CompletionJul 13, 2022
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 5.9 years ago

Interventions

Methadone Injectable Productdrug

Perioperative use of placebo for pain management and remifentanil during the surgery.