CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 27 enrolled
Drug / intervention
Endotoxindrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04527185
NCT04527185Phase 2Completed
CompareCT.gov

Does Endotoxin Administration Increase Alcohol Consumption in Individuals With AUD?

Yale University·interventional·Posted Aug 26, 2020·Updated Nov 3, 2025

In Brief

A Phase 2 clinical trial evaluating Endotoxin for Alcohol Use Disorder. Completed, enrolled 27 participants across 1 site.

Detailed Summary

For this protocol, the investigators plan to collect pilot data to examine the effect of endotoxin on drinking behavior in the human laboratory.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlcohol Use Disorder
CountriesUnited States
CollaboratorsNational Institute on Alcohol Abuse and Alcoholism (NIAAA)

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedAug 26, 2020
Enrollment StartFeb 27, 2022
Primary CompletionOct 31, 2024
TodayJul 2, 2026
Enrollment to primary: 2.7 yearsPosted 5.9 years ago

Interventions

Endotoxindrug

Endotoxin 0.4ng/kg i.v.