At a glance
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Randomized Trial of Universal vs. Guideline-directed Germline Testing Among Young Adults With Cancer
In Brief
A clinical study evaluating Broad gene panel for young adult cancers and Standard for Cancer. Completed, enrolled 749 participants across 1 site.
Detailed Summary
The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. The investigators hypothesize that panel-based universal screening coupled with electronic medical record- (EMR-) based algorithms can improve ascertainment of genetic risk by functioning as an automated, radically simplified default practice in place of repeated single decisions requiring clinician cognitive effort and action. A secondary goal is to explore differences in ascertainment of genetic risk among first-degree relatives of probands.
Study Details
Timeline
Interventions
Genetic testing will occur using a broad gene panel for young adult cancers
Those in the standard group who are considered high risk will have genetic testing done using the standard of care panel as selected by their care provider.