CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 49 enrolled
Drug / intervention
CogXergaming +1 morebehavioral
Likely dose
Not stated in record
Key inclusion· 7
  • Age 60 years or older
  • Walking speed <0.8 m/s
  • Physical activity <3 hours per week (self-reported)
  • Hand grip strength <30 kgs for men, <20 kgs for women
Key exclusion· 8
  • Heart rate >85% of age-predicted maximal heart rate at rest
  • Systolic blood pressure >165 mmHg or diastolic >110 mmHg at rest
  • Resting oxygen saturation <90%
  • Unable to stand for 5 minutes without assistive device

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04534686
NCT04534686N/ACompleted

CogXergaming to Promote Physical Activity and Cognitive Function to Enhance Community Mobility and Quality of Life in Frail Older Adults

University of Illinois at Chicago·interventional·Posted Sep 1, 2020·Updated Aug 28, 2025

In Brief

A clinical study evaluating CogXergaming and Matter of Balance Training for Frail Older Adults. Completed, enrolled 49 participants across 1 site.

Detailed Summary

Due to the age associated sarcopenia and reduced cardiovascular fitness, frail older adults experience significant decrease in physical function which comprises of mobility, endurance, muscle strength and balance control. The impaired physical function results in poor quality of life and reduced community participation, leading to increased frailty and long-term disability. Further, compared to cognitively intact frail older adults, cognitively impaired frail older adults experience greater deterioration of such physical function, specifically during dual-task performances (i.e., simultaneous performance of cognitive and motor task). This deterioration occurs due to increased cognitive-motor interference as a result of dual-tasking and is known to increase exhaustion among frail older adults. Previous studies have used multicomponent training and have shown to improve physical function and maintain cardiovascular functioning. However, the capacity of such interventions to improve cognitive function along with physical function is not known or unclear. Further, the concurrent comorbidities that occur along with psychosocial issues such as depression present as barriers and lead to reduced compliance to therapy leaving only a few of them to benefit from it. Alternate forms of therapy such as exergaming with explicit cognitive training has shown promising effects in improving motor and motor function in disabled populations. These studies use a cost-effective, off the shelf device such as Nintendo Wii or Microsoft Kinect to deliver the training which is easily available and clinically translatable. Further, such training has demonstrated increase in brain connectivity enhancing cognitive functions associated with balance control. However, there is limited literature examining the effect of exergaming in older frail population and the efficacy of such training is unknown. Therefore, this study proposes a randomized controlled trial to examine the feasibility of CogXergaming program with an aim to improve locomotor-balance control, cognition, muscular system and cardiovascular fitness.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedSep 1, 2020
Enrollment StartJan 10, 2021
Primary CompletionDec 5, 2022
Study CompletionMar 15, 2023
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 5.8 years ago

Interventions

CogXergamingbehavioral

The participant will play four of the six balance board games Table tilt, Tightrope, Soccer, Balance bubble, Light Run and Basic Step (each game is max 1.5 minutes). Each game will be superimposed with any 3 of the 6 cognitive tasks (word list generation consisting of verbal fluency (VF) and category fluency (CF), digit recall (DR), analogies (AN), mental arithmetic (MA), repeated letter (RL). The cognitive tasks will be randomized making sure that all the cognitive tasks are played with all the games. The cognitive and balance board game scores will be noted on the scoring sheet for each session. A total 10 minutes rest interval between every sub-session will be mandatorily provided.

Matter of Balance Trainingbehavioral

The program emphasizes practical coping strategies that include group discussions, mutual problem solving, exercises to improve strength, coordination and balance, and, a home safety evaluation.