At a glance
ClinicalIndex Comparison RecordEarly Ph 1Completed· 16 enrolled
Drug / intervention
Nicotinedrug
Likely dose
Nicotine 1 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Impact of Menthol on the Abuse Potential of Nicotine
In Brief
A Early Phase 1 clinical trial evaluating Nicotine for Nicotine Dependence. Completed, enrolled 16 participants across 1 site.
Detailed Summary
To examine if switching from menthol to non-menthol cigarettes will change the dose-effect curves for positive subjective effects and alleviation of smoking urges as a function of nicotine delivery rate in smokers.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNicotine Dependence
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)
Timeline
Early Ph 1CompletedFinished
202120222023202420252026
First PostedSep 2020
Enrollment StartJun 2021
Primary CompletionJun 2023
TodayJul 2026
First PostedSep 1, 2020
Enrollment StartJun 28, 2021
Primary CompletionJun 29, 2023
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 5.8 years ago
Interventions
Nicotinedrug
session will include 3 infusions in the same order: nicotine (1 mg per 70 kg body weight) delivered over 5 minutes, saline and nicotine (1 mg/ 70 kg) delivered over 2.5 minutes.