CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 86 enrolled
Drug / intervention
Pegozafermin +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04541186
NCT04541186Phase 2Completed

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Explore the Efficacy and Safety of BIO89-100 in Subjects With Severe Hypertriglyceridemia

89bio, Inc.·interventional·Posted Sep 9, 2020·Updated Jul 25, 2024

In Brief

A Phase 2 clinical trial evaluating Pegozafermin and Placebo for Severe Hypertriglyceridemia. Completed, enrolled 86 participants across 48 sites in 4 countries.

Detailed Summary

This study is designed to assess the efficacy, safety, and tolerability of different doses and dose regimens (once weekly \[QW\] or every 2 weeks \[Q2W\]), subcutaneous (SC) dosing of BIO89-100 (pegozafermin) compared to placebo in participants with severe hypertriglyceridemia (SHTG).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCzechia, Hungary, Poland, United States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedSep 9, 2020
Enrollment StartSep 1, 2020
Primary CompletionMay 19, 2022
Study CompletionMay 31, 2022
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 5.8 years ago

Interventions

Pegozafermindrug

Subcutaneous injection

Placebodrug

Matching placebo