At a glance
ClinicalIndex Comparison Record- ✓Age 18 years or older
- ✓Confirmed HIV-positive diagnosis
- ✓Undetectable HIV viral load (< 200 copies/mL) within past 18 months
- ✓Hypertension with average systolic BP ≥130 and/or diastolic ≥90 mmHg on most recent 4 outpatient measurements in past 18 months
- ✕Severe hearing or speech impairment or other disability limiting participation
- ✕Resident in nursing home or long-term care facility at baseline
- ✕Current inpatient psychiatric hospitalization
- ✕Dementia diagnosis or active psychosis
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Nurse-led Intervention to Extend the Veteran HIV Treatment Cascade for Cardiovascular Disease Prevention (V-EXTRA-CVD)
In Brief
A clinical study evaluating Intervention group and Education control group for Cardiovascular Disease and 3 related conditions. Completed, enrolled 305 participants across 4 sites.
Detailed Summary
The VA is the largest single provider of HIV care in the US and Veterans with HIV use significantly more healthcare services and have a 1.5-2x higher risk of atherosclerotic cardiovascular disease (ASCVD) compared to uninfected Veterans. The goal is to improve BP treatment for Veterans with HIV to reduce ASCVD risk. Within a randomized controlled trial (RCT), the investigators hypothesize that the VA adapted nurse-led intervention will result in a clinically significant 6 millimeters of mercury (mmHg) reduction in systolic blood pressure (SBP) over 12 months compared to those receiving enhanced education only. The study is innovative because of the use of stakeholder-engaged design process, multi-component nurse-led intervention, and VA Video Connect (VVC) to monitor CVD risk factors. The project meets VA strategic priorities including: 1) greater choice for Veterans; 2) improve timeliness of services; 3) focus more resources more efficiently (strengthen foundational services in VA). If shown to be effective, this intervention will have substantial impact among high-risk Veterans, potentially reducing ASCVD events by more than a quarter.
Study Details
Timeline
Interventions
This is a intervention for 12 months which focuses on behavioral and medication management, led by a health coach (nurse or pharmacist)
This group will receive education materials related to CVD risk reduction at each 4 month visit over the course of 12 months.