CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 36 enrolled
Drug / intervention
Placebo +1 moredietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04557228
NCT04557228N/ACompleted

Targeting ADAM17 Activity for Correction of Vascular Insulin Resistance in Type 2 Diabetes

University of Missouri-Columbia·interventional·Posted Sep 21, 2020·Updated May 4, 2026

In Brief

A clinical study evaluating Placebo and Phosphatidylserine for Diabetes Mellitus, Type 2. Completed, enrolled 36 participants across 1 site.

Detailed Summary

The objective of this project is to determine the extent to which administration of the dietary supplement phosphatidylserine (PS), a competitive inhibitor of ADAM17 sheddase activity, effects vascular function and insulin-stimulated leg blood flow in subjects with T2D.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedSep 21, 2020
Enrollment StartMar 1, 2023
Primary CompletionFeb 3, 2025
Study CompletionNov 1, 2025
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 5.8 years ago

Interventions

Placebodietary

4 weeks of placebo supplements

Phosphatidylserinedietary

4 weeks of phosphatidylserine supplements