CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 4,017 enrolled
Drug / intervention
Dapagliflozin +1 moredrug
Likely dose
Dapagliflozin 10 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04564742
NCT04564742Phase 3Completed

A Registry-based, Randomised, Double-blind, Placebo-Controlled Cardiovascular Outcomes Trial to Evaluate the Effect of Dapagliflozin on Cardiometabolic Outcomes in Patients Without Diabetes With Acute Myocardial Infarction at Increased Risk for Subsequent Development of Heart Failure

AstraZeneca·interventional·Posted Sep 25, 2020·Updated Mar 7, 2025

In Brief

A Phase 3 clinical trial evaluating Dapagliflozin and Placebo for Acute Myocardial Infarction and Heart Failure. Completed, enrolled 4,017 participants across 103 sites in 2 countries.

Detailed Summary

This study will evaluate the effect of dapagliflozin versus placebo, given once daily in addition to Standard of Care (SoC) therapies for patients with myocardial infarction (MI), for hospitalisation for heart failure (HHF), cardiovascular (CV) death, and other cardiometabolic outcomes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesSweden, United Kingdom
CollaboratorsUppsala University

Timeline

Phase 3CompletedFinished
202120222023202420252026
First PostedSep 25, 2020
Enrollment StartDec 22, 2020
Primary CompletionJul 5, 2023
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 5.8 years ago

Interventions

Dapagliflozindrug

Dapagliflozin 10 mg tablets given once daily, per oral use

Placebodrug

Placebo matching dapagliflozin 10 mg tablets given once daily, per oral use