At a glance
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The Bacteriology of Pleural Infection Using Next Generation Sequencing: The Oxford Pleural Infection Metagenomics Studies (TORPIDS)
In Brief
An observational study evaluating Not applicable. Observational study. Retrospective analysis of samples. for Pleural Infection and Pleural Infection Bacterial. Completed, enrolled 251 participants across 1 site.
Detailed Summary
Pleural Infection (PI) is a common, severe and complicated disease with considerable morbidity and mortality. (1,2) The knowledge of pleural infection microbiology remains incomplete. Sequencing of the bacterial 16S rRNA gene is a reliable methodology to discover the total microbiome of complex samples. The investigators designed a translational metagenomics study to study the bacteriology of pleural infection. The investigators will use pleural fluid specimens from a) the "Prospective validation of the RAPID clinical risk prediction score in adult patients with pleural infection: the PILOT study" (3) clinical trial and b) non-pleural infection patients. The pleural fluid specimens will be subjected to 16S rRNA next generation sequencing.
Study Details
Timeline
Interventions
Not applicable. Observational study. Retrospective analysis of samples.