CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 50 enrolled
Drug / intervention
Comprehensive Behavioral Intervention for Tics (CBIT) +2 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04578912
NCT04578912N/ACompleted
CompareCT.gov

Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics

University of Minnesota·interventional·Posted Oct 8, 2020·Updated Mar 7, 2025

In Brief

A clinical study evaluating Comprehensive Behavioral Intervention for Tics (CBIT), Repetitive Transcranial Magnetic Stimulation (rTMS), and 1 other intervention for Tic Disorders and 6 related conditions. Completed, enrolled 50 participants across 1 site.

Detailed Summary

The study will examine whether combining Comprehensive Behavioral Intervention for Tics (CBIT) with inhibition of the supplementary motor area (SMA) using transcranial magnetic stimulation (TMS) normalizes activity in the SMA-connected circuits, improves tic suppression ability, and enhances CBIT outcomes in young people with tic disorder. The study will also examine different TMS dosing strategies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTic Disorders, Tics, Tic, Motor, Tic Disorder, Childhood, Tourette Syndrome, Tourette Syndrome in Children, Tourette Syndrome in Adolescence
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedOct 8, 2020
Enrollment StartNov 1, 2020
Primary CompletionDec 31, 2023
TodayJul 2, 2026
Enrollment to primary: 3.2 yearsPosted 5.7 years ago

Interventions

Comprehensive Behavioral Intervention for Tics (CBIT)behavioral

CBIT is a manualized treatment program focused on tic management skills

Repetitive Transcranial Magnetic Stimulation (rTMS)device

During repetitive transcranial magnetic stimulation (rTMS), a electromagnetic coil is placed against the scalp while an electromagnet painlessly delivers a magnetic pulse that stimulates nerve cells in the target brain region

Continuous Theta Burst Stimulation (cTBS)device

During continuous theta burst stimulation (cTBS), a electromagnetic coil is placed against the while an electromagnet painlessly delivers magnetic bursts that stimulate nerve cells in the target brain region