CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 100 target
Drug / intervention
Hyperpolarized Xenon-129 MRI of the lungs +6 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04584671
NCT04584671N/AActiveOn TrackUpdated 10mo ago
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Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection: 129Xe MRI and CT For Rapid Evaluations and NExt-wave Healthcare Planning

Western University, Canada·observational·Posted Oct 14, 2020·Updated Aug 14, 2025

In Brief

An observational study evaluating Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), and 5 other interventions for Covid19. Active but no longer recruiting, targeting 100 participants across 1 site.

Detailed Summary

This is a longitudinal study of the long-term impact of COVID-19 on the lungs. Participants will be followed over a period of up to 4 years and impacts of COVID-19 on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129, pulmonary function tests, exercise capacity, computed tomography imaging and questionnaires.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsCovid19
CountriesCanada
CollaboratorsLondon Health Sciences Centre

Timeline

N/AActive
2021202220232024202520262027
First PostedOct 14, 2020
Enrollment StartJan 1, 2021
Primary CompletionSep 1, 2026
Study CompletionDec 1, 2026
TodayJul 2, 2026
Enrollment to primary: 5.7 yearsPosted 5.7 years agoPrimary completion in 2 months

Interventions

Hyperpolarized Xenon-129 MRI of the lungsother

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

Computed Tomography (CT)other

Participants will undergo a CT scan of the thoracic cavity

Pulmonary Function Tests (PFT)other

Participants will have their lung function evaluated using PFT

Six Minute Walk Test (6MWT)other

Participants will perform the six minute walk test as a measure of exercise capacity

Sputum analysisother

Participants will provide a sputum sample that will be analysed for eosinophils

Blood analysisother

Participants will have their blood drawn and analysed for eosinophil count.

Questionnairesother

Participants will complete questionnaires to assess activity related dyspnea, respiratory symptoms and health status impairment and respiratory related quality of life.