At a glance
ClinicalIndex Comparison RecordEarly Ph 1Completed· 34 enrolled
Drug / intervention
Sodium Bicarbonate Tablets +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
In Brief
A Early Phase 1 clinical trial evaluating Sodium Bicarbonate Tablets and Placebo for Metabolic Acidosis and 2 related conditions. Completed, enrolled 34 participants across 1 site.
Detailed Summary
This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on cognitive and cerebrovascular function.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--
Timeline
Early Ph 1CompletedFinished
202120222023202420252026
First PostedOct 2020
Enrollment StartFeb 2021
Primary CompletionAug 2023
TodayJul 2026
First PostedOct 23, 2020
Enrollment StartFeb 1, 2021
Primary CompletionAug 30, 2023
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 5.7 years ago
Interventions
Sodium Bicarbonate Tabletsdrug
Participants will be given sodium bicarbonate at 0.5 mEq/kg-LBW/day for 12 months
Placebodrug
Participants will be given placebo at 0.5 mEq/kg-LBW/day for 12 months