At a glance
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Pragmatic Urinary Sodium-based Treatment algoritHm in Acute Heart Failure
In Brief
A clinical study evaluating Natriuresis for Heart Failure Acute. Completed, enrolled 310 participants across 1 site.
Detailed Summary
Administration of loop diuretics to achieve decongestion is the current cornerstone of therapy for acute heart failure. Unfortunately, there is a lack of evidence of how to guide diuretic treatment. Recently, urinary sodium, as a response measure of diuretic response, has been proposed as a target for therapy. The hypothesis of this study is that natriuresis guided therapy in patients with acute heart failure will improve diuretic response, decongestion, and reduce length of hospital stay, as well as heart failure rehospitalisations.
Study Details
Timeline
Interventions
Patients with insufficient decongestive response based on natriuresis (in the active arm) will be eligible for treatment adjustments according to the natriuresis guided treatment algorithm.