CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 24 enrolled
Drug / intervention
NBI-827104 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04625101
NCT04625101Phase 2Completed

Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of NBI-827104 in Pediatric Subjects With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep

Neurocrine Biosciences·interventional·Posted Nov 12, 2020·Updated Sep 5, 2025

In Brief

A Phase 2 clinical trial evaluating NBI-827104 and Placebo for Epileptic Encephalopathy and Continuous Spike and Wave During Sleep. Completed, enrolled 24 participants across 15 sites in 6 countries.

Detailed Summary

This is a phase 2, double-blind study to assess the efficacy, safety, tolerability, and pharmacokinetics of NBI-827104 when administered once daily for 13 weeks in pediatric subjects with Epileptic Encephalopathy with Continuous Spike-and-Wave During Sleep (EECSWS).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, Denmark, Spain, Switzerland, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedNov 12, 2020
Enrollment StartApr 26, 2021
Primary CompletionAug 8, 2022
Study CompletionOct 11, 2022
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 5.6 years ago

Interventions

NBI-827104drug

Triple T-type calcium channel blocker.

Placebodrug

Non-active dosage form.