CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 145 enrolled
Drug / intervention
Simplify Disc +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04630626
NCT04630626N/ACompleted
CompareCT.gov

Extended Follow-up of Investigational Device Exemption (IDE) Subjects Treated With the Simplify Cervical Artificial Disc

NuVasive·interventional·Posted Nov 16, 2020·Updated Jan 8, 2026

In Brief

A clinical study evaluating Simplify Disc and ACDF for Cervical Degenerative Disc Disorder. Completed, enrolled 145 participants across 15 sites.

Detailed Summary

This study is intended to demonstrate the 5-year long-term safety and efficacy of the Simplify® Cervical Artificial Disc ("Simplify Disc") in subjects enrolled in the non-randomized Simplify Disc IDE study. This study was conducted under IDE G140154.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCervical Degenerative Disc Disorder
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedNov 16, 2020
Enrollment StartJan 1, 2021
Primary CompletionApr 23, 2023
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 5.6 years ago

Interventions

Simplify Discdevice

The Simplify Disc is a cervical artificial disc manufactured from polyether ether ketone (PEEK) endplates and a mobile, zirconia-toughened alumina ceramic core.

ACDFother

Historical ACDF control data