CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 30 enrolled
Drug / intervention
Bempegaldesleukin +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04646044
NCT04646044Phase 1Completed

A Phase 1b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) Plus Standard of Care Versus Placebo Plus Standard of Care in Adults With Mild COVID-19

Nektar Therapeutics·interventional·Posted Nov 27, 2020·Updated Mar 12, 2024

In Brief

A Phase 1 clinical trial evaluating Bempegaldesleukin, Standard of Care, and 1 other intervention for Covid-19 and Coronavirus Disease 2019. Completed, enrolled 30 participants across 4 sites.

Detailed Summary

The main purpose of this phase-1b, multicenter, randomized double-blind, placebo-controlled, trial is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of bempegaldesleukin (BEMPEG; NKTR-214) in combination with standard of care (SOC) in adult patients with mild COVID-19 (coronavirus disease 2019). The trial will also define the recommended phase 2 dose (RP2D) of bempegaldesleukin in patients with mild COVID-19.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
202120222023202420252026
First PostedNov 27, 2020
Enrollment StartNov 13, 2020
Primary CompletionMay 11, 2021
Study CompletionMay 18, 2021
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 5.6 years ago

Interventions

Bempegaldesleukindrug

Administered as an intravenous infusion

Standard of Caredrug

Standard of Care Treatment for COVID-19 Infection

Placeboother

Administered as an intravenous infusion