CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 65 enrolled / 65 target
Drug / intervention
Behavioral Therapy for Irritability in Autism +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04654260
NCT04654260N/ACompletedOn Track (1.0/mo)Completion was 2mo ago

Behavior Therapy for Irritability and Aggression in Adolescents With Autism

Yale University·interventional·Posted Dec 4, 2020·Updated Jun 12, 2026

In Brief

A clinical study evaluating Behavioral Therapy for Irritability in Autism and Psychoeducation and Supportive Therapy (PST) for Autism Spectrum Disorder and 6 related conditions. Completed, enrolled 65 participants across 1 site.

Detailed Summary

This is a clinical trial of a novel intervention, Behavioral Therapy for Irritability and Aggression (BTIA), for adolescents on the autism spectrum. The main goals of BTIA are to help adolescents develop emotion regulation skills to handle frustration and to strengthen skills for navigating the challenging and diverse experiences associated with the transition to adulthood. The study will test whether BTIA can be helpful to adolescents on the autism spectrum and to their families.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedDec 4, 2020
Enrollment StartDec 10, 2020
Primary CompletionMay 1, 2026
TodayJul 2, 2026
Enrollment to primary: 5.4 yearsPosted 5.6 years ago

Arms & Interventions

Behavioral Therapy for Irritability in Autism (BTIA)experimental

BTIA consists of 15 ninety-minute weekly sessions that will be conducted with the teens and their parents by experienced therapists using a structured, detailed manual.

Behavioral: Behavioral Therapy for Irritability in Autism
Psychoeducation and Supportive Therapy (PST)active_comparator

PST consist of 15 weekly, ninety-minute sessions focused on learning about and discussing issues of diagnosis, treatment and educational services with an experienced therapist could be helpful to children on the autism spectrum and their families.

Behavioral: Psychoeducation and Supportive Therapy (PST)

Interventions

Behavioral Therapy for Irritability in Autismbehavioral

The child-focused components of BTIA are organized in modules dedicated to emotion regulation, problem solving and practice of planned steps to prevent or resolve conflicts. Each session contains a set of six to seven goals, and each goal contains a menu of techniques and activities that can be used to attain this goal. In order to administer the treatment in a flexible yet reliable manner, the therapist works collaboratively with the child and his or her parents to select activities that are perceived as relevant for attaining the session's goal. The parent-focused components of BTIA include include education about the effects of antecedents and consequences on disruptive behavior, developing strategies for reducing or altering antecedent events that may lead to disruptive reactions and helping parents to use reinforcement of competent and calm responses in potentially frustrating situations.

Psychoeducation and Supportive Therapy (PST)behavioral

Each PST session will start with a review of events of the past week and include queries of topics such as school, interests, hobbies, and family with an overarching goal of enhancing subjective well-being. A major objective is to enables the participant to discuss his or her concerns with a therapist toward a goal of enhancing overall psychological wellbeing. Education about autism diagnosis and services is also provided to families as part of PST.