CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 496 enrolled
Drug / intervention
UCB0599 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04658186
NCT04658186Phase 2Completed

A Double-Blind, Placebo-Controlled, Randomized, 18-Month Phase 2a Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral UCB0599 in Study Participants With Early Parkinson's Disease

UCB Biopharma SRL·interventional·Posted Dec 8, 2020·Updated Oct 31, 2025

In Brief

A Phase 2 clinical trial evaluating UCB0599 and Placebo for Early-stage Parkinson's Disease. Completed, enrolled 496 participants across 115 sites in 9 countries.

Detailed Summary

The purpose of the study is to assess the safety and tolerability of UCB0599 and to demonstrate the superiority of UCB0599 over placebo with regard to clinical symptoms of disease progression over 12 and 18 months in participants diagnosed with early-stage Parkinson's Disease.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, France, Germany, Italy, Netherlands, Poland, Spain, United Kingdom, United States

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedDec 8, 2020
Enrollment StartDec 30, 2020
Primary CompletionSep 6, 2024
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 5.6 years ago

Interventions

UCB0599drug

Drug: UCB0599 Pharmaceutical form: Granules in capsules Route of administration: Oral use Participants will receive UCB0599 in a pre-specified sequence during the Treatment Period.

Placebodrug

Drug: Placebo Pharmaceutical form: Capsules Route of administration: Oral use Participants will receive Placebo in a pre-specified sequence during the Treatment Period.