At a glance
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Treatment of Stress-Related Psychopathology: Targeting Maladaptive and Adaptive Event Processing
In Brief
A clinical study evaluating Positive Processes and Transition to Health (PATH) for Major Depressive Disorder and Post Traumatic Stress Disorder. Completed, enrolled 45 participants across 3 sites.
Detailed Summary
The R61 will be an open trial to determine if Positive Processes and Transition to Health (PATH) engages the proposed targets: unproductive processing, avoidance, and reward deficits in a sample of 45 adults who have experienced a destabilizing life event involving profound loss or threat, report persistent stressor-related symptoms of PTSD and/or depression, and are elevated on symptoms related to 2 of the 3 therapeutic targets. Additionally, will examine whether patients perceive PATH as helpful and complete/adhere to treatment, and therapist fidelity. Patients will receive 6 sessions of PATH (with 2 boosters, if partial responders). Primary targets will be assessed at pre-treatment, week 4, post-treatment, and at 1- and 3-month follow-up; secondary targets at pre-treatment, weekly during treatment, post-treatment, and at 1- and 3-month follow-ups.
Study Details
Timeline
Interventions
See arm/group description for details regarding this intervention