CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 7,500 enrolled
Drug / intervention
16S rRNA gene sequencing of cervical secretionsother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04694495
NCT04694495N/ACompleted
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HPV Infection and Genital Microecology of Childbearing-age Female in China: A Cohort and Multicenter Study

Zhujiang Hospital·observational·Posted Jan 5, 2021·Updated Jun 27, 2025

In Brief

An observational study evaluating 16S rRNA gene sequencing of cervical secretions for Papillomavirus Infections and 2 related conditions. Completed, enrolled 7,500 participants across 42 sites.

Detailed Summary

The purpose of this study to access the relations between genital microecology, HPV infection and cervical intraepithelial neoplasia of childbearing-age female in China

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsPapillomavirus Infections, Uterine Cervical Neoplasms, Sexual Transmitted Disease
CountriesChina
CollaboratorsPeking University First Hospital, The Affiliated Hospital Of Guizhou Medical University, Hainan General Hospital, LanZhou University, Lianyungang Hospital Affiliated Bengbu Medical College, General Hospital of Ningxia Medical University, Jinan Central Hospital, Tibet Autonomous Region People's Hospital, The Affiliated Hospital Of Southwest Medical University, Anhui Provincial Hospital, The First People's Hospital of Zunyi, The Third Affiliated Hospital of Southern Medical University, First Affiliated Hospital, Sun Yat-Sen University, Zhuhai Center for Maternal and Child Health Care, First Affiliated Hospital of Guangxi Medical University, Qinghai Red Cross Hospital, Changzhi People's Hospital, Shanghai East Hospital, Fifth Affiliated Hospital of Guangzhou Medical University, Huizhou Municipal Central Hospital, Nanfang Hospital, Southern Medical University, Yuebei People's Hospital, The Seventh Affiliated Hospital of Sun Yat-sen University, Fujian Maternity and Child Health Hospital, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Henan Provincial People's Hospital, The Fifth Affiliated Hospital of Southern Medical University, Shandong Provincial Hospital, First Hospital of China Medical University, Gansu Provincial Hospital

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedJan 5, 2021
Enrollment StartNov 12, 2020
Primary CompletionDec 31, 2024
TodayJul 2, 2026
Enrollment to primary: 4.1 yearsPosted 5.5 years ago

Interventions

16S rRNA gene sequencing of cervical secretionsother

1. 16S rRNA gene sequencing of vaginal secretions: using NGS technology to assess the microbiota of the vaginal secretions 2. Microecology assessment of vaginal secretions: morphology test, functional assessment and Nugent score assessment of the vaginal secretions are included. 3. Genotyping of HPV and detection of sexually transmitted diseases pathogens based on the cervical exfoliated cells 4. Thinprep cytologic test of cervical exfoliated cells: to evaluate the grade of cervical intraepithelial neoplasia