At a glance
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Extracellular Vesicles as Biomarkers for Chronic Renal Failure
In Brief
A clinical study evaluating urinary extracellular vesicle concentration and blood sample for Chronic Renal Failure and Urinary Extracellular Vesicle. Completed, enrolled 143 participants across 1 site.
Detailed Summary
The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.
Study Details
Timeline
Interventions
urinary extracellular vesicle concentration will be determined in urine samples from CRF and healthy patients
blood sample in order to determine creatin level