CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 48 enrolled
Drug / intervention
Exerciseother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04700800
NCT04700800N/ACompleted
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Regulation of Muscle Protein Phenotype in Humans With Obesity

Mayo Clinic·interventional·Posted Jan 8, 2021·Updated Nov 5, 2025

In Brief

A clinical study evaluating Exercise for Obesity. Completed, enrolled 48 participants across 1 site.

Detailed Summary

A hallmark of muscle changes in obesity is an altered muscle fiber type profile, characterized by a reduced proportion of Type I fibers - a shift associated with adverse obesity-related health outcomes. This alteration can be linked to changes in the expression of myosin heavy chain (MHC) protein isoforms in the skeletal muscle of individuals with obesity. The investigators aim to modulate the metabolism of muscle MHC isoforms to uncover the biological mechanisms underlying this disrupted expression pattern in muscle of humans with obesity.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsObesity
CountriesUnited States
CollaboratorsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedJan 8, 2021
Enrollment StartOct 7, 2021
Primary CompletionOct 2, 2024
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 5.5 years ago

Interventions

Exerciseother

Exercise at 65% of heart rate reserve