At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity
In Brief
A Phase 2 clinical trial evaluating Hyperinsulemic euglycemic clamp, Muscle Biopsy, and 2 other interventions for Pre Diabetes. Completed, enrolled 5 participants across 1 site.
Detailed Summary
The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.
Study Details
Timeline
Interventions
Following a 12-hour overnight fast at the CRU (including abstinence from caffeine containing foods and beverages), insulin sensitivity will be measured using the criterion method of the euglycemic clamp. Participants will have not performed vigorous physical activity for at least the previous 24 h, and be free of acute illness for the prior 2 weeks. An intravenous catheter will be placed in an antecubital vein for subsequent insulin (40 mU/m2-min) and glucose infusions and for stable isotope (6, 6-2H2) infusions to measure insulin sensitivity.
One biopsy taken prior to clamp and a second biopsy taken 30-45 min after the start of the clamp. A biopsy of the Vastus Lateralis muscle will be performed on the leg/thigh using the Bergstrom technique.
Those in this group will receive ABA (95 µg ABA and 300 mg of corn starch)
Those in this group will receive placebo (300 mg cornstarch)