CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 56 enrolled / 56 target
Drug / intervention
Famotidine +1 moredrug
Likely dose
80mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04724720
NCT04724720Phase 2CompletedOn Track (0.9/mo)Completion was 61mo ago
CompareCT.gov

A Randomized, Double-Blind, Comparative Trial of the Safety and Efficacy of Famotidine vs Placebo for the Treatment of Non-Hospitalized Symptomatic Adults With COVID-19

Northwell Health·interventional·Posted Jan 26, 2021·Updated Jun 15, 2026

In Brief

A Phase 2 clinical trial evaluating Famotidine and Placebo for Covid-19. Completed, enrolled 56 participants across 1 site.

Detailed Summary

The overall objective of this study is to evaluate the clinical efficacy of oral famotidine in symptomatic non-hospitalized patients with confirmed COVID-19. This study is expected to enroll up to 84 patients with mild to moderate symptoms divided into each of the two study arms. Clinical outcomes of the two treatment arms will be compared. This study will be conducted virtually/remotely.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCovid-19
CountriesUnited States
CollaboratorsCold Spring Harbor Laboratory

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedJan 26, 2021
Enrollment StartJan 19, 2021
Primary CompletionMay 3, 2021
Study CompletionJan 25, 2022
TodayJul 2, 2026
Enrollment to primary: 3 monthsPosted 5.4 years ago

Arms & Interventions

Famotidineactive_comparator

Participants in this study arm will receive standard of care and prescribed famotidine at 80mg TID for a maximum of 14 days, or until hospital admission.

Drug: Famotidine
Placeboplacebo_comparator

Participants in this study arm will receive standard of care and placebo for a maximum of 14 days.

Drug: Placebo

Interventions

Famotidinedrug

Standard or care treatment plus prescribed famotidine

Placebodrug

Standard of care treatment plus placebo