At a glance
ClinicalIndex Comparison Record- ✓Histopathology-proven MIBC on TURb or ≥T3 on imaging
- ✓T1-4 N0-3 M0 MIBC staging on conventional imaging
- ✓Age over 18 years
- ✓Willingness to undergo 18F-FDG-PET-CT imaging
- ✕Distant metastasis on conventional imaging
- ✕Refusal or contraindications to 18F-FDG-PET-CT
- ✕Refusal of MDT or immunotherapy
- ✕Prior radiotherapy preventing MDT delivery
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluating the Impact of 18F-FDG-PET-CT on Risk Stratification and Treatment Adaptation for Patients with Muscle Invasive Bladder Cancer (EFFORT-MIBC): a Phase II Prospective Trial
In Brief
A Phase 2 clinical trial evaluating Metastasis directed therapy (MDT), Immunotherapy, and 1 other intervention for Muscle-Invasive Bladder Carcinoma. Currently recruiting, targeting 156 participants across 1 site.
Detailed Summary
Evaluate the impact of 18F-FDG-PET-CT on the staging of patients with muscle invasive bladder cancer. Based on the results of 2 18F-FDG-PET-CT's patients are stratified in non-metastatic, oligometastatic and polymetastatic bladder cancer patients and the treatment is adapted accordingly to improve overall survival.
Study Details
Timeline
Interventions
Patient receives standard of care therapy with either radical cystectomy with pelvic lymph node dissection or trimodality therapy (consisting of a visible complete TURb and radio chemotherapy). Concurrently, the oligometastasis will be treated with stereotactic body radiotherapy or metastasectomy.
Patient receives standard of care therapy with either radical cystectomy with pelvic lymph node dissection or trimodality therapy (consisting of a visible complete TURb and radio chemotherapy). Afterwards immunotherapy will be initiated and regular follow up will be performed.
Patient receives standard of care therapy with either radical cystectomy with pelvic lymph node dissection or trimodality therapy (consisting of a visible complete TURb and radio chemotherapy). Afterwards regular follow up is performed.