CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 212 target
Drug / intervention
FIRST +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04725721
NCT04725721N/AActiveOn TrackUpdated 2mo ago

Testing FIRST in Youth Outpatient Psychotherapy

Harvard University·interventional·Posted Jan 27, 2021·Updated Apr 17, 2026

In Brief

A clinical study evaluating FIRST and Usual Care for Anxiety and 3 related conditions. Active but no longer recruiting, targeting 212 participants across 2 sites.

Detailed Summary

The study will compare the impact FIRST (a transdiagnostic treatment built upon five empirically supported principles of change) versus usual care outpatient psychotherapy on youths' mental health outcomes and a candidate mechanism of change: regulation of negative emotions.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/AActive
2021202220232024202520262027
First PostedJan 27, 2021
Enrollment StartSep 27, 2021
Primary CompletionFeb 1, 2027
TodayJul 2, 2026
Enrollment to primary: 5.3 yearsPosted 5.4 years agoPrimary completion in 7 months

Interventions

FIRSTbehavioral

FIRST is built upon five empirically supported principles of change (ESPCs-i.e., feeling calm, increasing motivation, repairing thoughts, solving problems, trying the opposite). Each principle can be applied to treatment of problems spanning depression, anxiety (including OCD and PTS), and conduct problems-thus encompassing a majority of the youths seen in outpatient care. Its design addresses breadth of problem coverage, youth comorbidity, and flux in youth treatment needs during episodes of care. It is used in conjunction with performance feedback via a web-based tracking system that gives clinicians weekly data on youth treatment response. FIRST has treatment and training efficiency, and efficient clinician skill-building is supported by group consultation.

Usual Carebehavioral

Treatment in the usual care (UC) condition will use the clinical procedures therapists consider appropriate and believe to be effective.