CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 255 enrolled
Drug / intervention
Moxidectin 2 mg Oral Tablet +2 moredrug
Likely dose
Moxidectin 2 mg Oral Tabletfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04726969
NCT04726969Phase 3Completed
CompareCT.gov

Efficacy and Safety of Combination Moxidectin and Albendazole, Ivermectin and Albendazole and Albendazole Alone in Adolescents and Adults Infected With Trichuris Trichiura: a Randomized Controlled Trial

Jennifer Keiser·interventional·Posted Jan 27, 2021·Updated Jan 24, 2024

In Brief

A Phase 3 clinical trial evaluating Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet, and 1 other intervention for Trichuriasis and 2 related conditions. Completed, enrolled 255 participants across 1 site.

Detailed Summary

This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole versus albendazole monotherapy (standard of care) against whipworm (T. trichiura) infections in adolescents and adults (12-60 years) in Côte d'Ivoire. One arm of patients will be treated with albendazole-ivermectin. As measure of efficacy of the treatment the cure rate (percentage of egg-positive subjects at baseline who become egg-negative after treatment) will be determined 14-21 days post-treatment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTrichuriasis, Ascariasis, Hookworm Infections
CountriesCôte d’Ivoire
CollaboratorsCentre Suisse de Recherches Scientifiques en Cote d'Ivoire

Timeline

Phase 3CompletedFinished
202120222023202420252026
First PostedJan 27, 2021
Enrollment StartJun 15, 2021
Primary CompletionSep 9, 2021
TodayJul 2, 2026
Enrollment to primary: 3 monthsPosted 5.4 years ago

Interventions

Moxidectin 2 mg Oral Tabletdrug

Tablets of 2 mg moxidectin

Albendazole 400 mg Oral Tabletdrug

Tablets of 400 mg albendazole

Ivermectin 3 mg Oral Tabletdrug

Tablets of 3 mg ivermectin