At a glance
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Effect of Postprandial Hyperglycemia on Vasculature in Type 1 Diabetes and Healthy Adults
In Brief
An observational study evaluating Mixed Meal for Type 1 Diabetes and Hyperglycemia, Postprandial. Completed, enrolled 36 participants across 1 site.
Detailed Summary
To the investigator's knowledge, there are no data available in the current literature regarding the acute effects of postprandial hyperglycemia and insulin timing on myocardial perfusion in people with type 1 diabetes (T1D). Observational studies using CEU in type 2 diabetes demonstrate that postprandial hyperglycemia determines myocardial perfusion defects. The investigator hypothesizes that the combination of postprandial hyperglycemia and insulin increases pulse wave velocity (i.e., aortic stiffness) and myocardial vasoconstriction, thereby reducing myocardial perfusion in T1D when compared to healthy controls. Furthermore, the investigator hypothesizes in T1D that dosing insulin before meal intake will ameliorate these cardiovascular defects.
Study Details
Timeline
Interventions
the meal will be 40% of each subject's daily estimated caloric need, with 50%, 30%, 20% from carbohydrates, fat and protein, respectively