At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Controlled Examiner-blind Phase ii Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate, High Molecular Weight Sodium Hyaluronate and Sodium Fluoride on Gingivitis and Plaque Removal in a Population With Mild-moderate Plaque-induced Gingivitis
In Brief
A Phase 2 clinical trial evaluating Experimental Dentrifrice, Positive control dentifrice, and 1 other intervention for Gingivitis. Completed, enrolled 110 participants across 1 site.
Detailed Summary
The aim of this study is to develop a daily use toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride with the intention of providing improved/ fast gum healing. This Proof-of-Principle study will investigate the efficacy of an experimental dentifrice compared to a regular fluoride dentifrice, and also whether this provides any additional benefit in reducing gingival inflammation/ bleeding compared with a 67% w/w sodium bicarbonate/ 0.221% w/w sodium fluoride containing toothpaste.
Study Details
Timeline
Interventions
Toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride
Dentifrice containing 67% w/w sodium bicarbonate and 0.221% w/w sodium fluoride
Dentifrice containing 1100ppm fluoride as sodium fluoride (Crest Cavity Protection)