CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 685 enrolled
Drug / intervention
Tobacco Use Treatment Service and Varenicline Managementother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04738643
NCT04738643N/ACompleted

Improving Tobacco Treatment Rates for Cancer Patients Who Smoke

Abramson Cancer Center at Penn Medicine·interventional·Posted Feb 4, 2021·Updated May 8, 2025

In Brief

A clinical study evaluating Tobacco Use Treatment Service and Varenicline Management for Cancer and 3 related conditions. Completed, enrolled 685 participants across 2 sites.

Detailed Summary

The research objective is to identify a simple, pragmatic, innovative way of enhancing Tobacco Use Treatment (TUT) rates within oncology. To investigate this possibility, the investigators propose methods that will allow them to: 1) evaluate the impact of standing orders to initiate a varenicline management protocol within outpatient cancer treatment workflow, 2) assess the potential for an EHR-based intervention to affect patient TUT behaviors, and 3) identify important facilitators and barriers that impact effectiveness of the intervention. The investigators will assess whether including a standing order for prescription and management of varenicline (TUT Service+VM) within the workflow for cancer patients identified as current smokers will significantly increase TUT engagement rates compared to current standard of care (TUT Service alone). The investigators hypothesize that observed treatment engagement rates will be higher among clinicians exposed to TUT Service+VM than observed in clinicians exposed to TUT Service alone.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
202120222023202420252026
First PostedFeb 4, 2021
Enrollment StartJun 28, 2022
Primary CompletionDec 31, 2023
Study CompletionJan 24, 2024
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 5.4 years ago

Interventions

Tobacco Use Treatment Service and Varenicline Managementother

The VM intervention builds upon the established TUT Service process. In addition to connecting the patient to TUT Service via electronic referral, it activates a medication management protocol that: 1) actively confirms no evidence of renal failure or pregnancy with oncology provider, 2) automates a referral to prescribing providers within the TUT Service team, prompting a call-back to patient within 24 hours, 3) provides written AVS instructions to contact TUT Service for initiation instructions and clinic appointment, and 4) pends a varenicline prescription to the medication list, ready for reconciliation by TUT Service prescribing clinicians. The protocol formalizes standard management principles for varenicline, including follow-up evaluation, pre-quit period duration, and side effect amelioration.