CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 31 enrolled
Drug / intervention
Durvalumab +4 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04745689
NCT04745689Phase 2Active

A Phase II Multicenter, Open-Label, Single Arm Study to Determine the Efficacy, Safety and Tolerability of AZD2811 and Durvalumab Combination as Maintenance Therapy After Induction With Platinum-Based Chemotherapy Combined With Durvalumab, for the First-Line Treatment of Patients With Extensive Stage Small-Cell Lung Cancer

AstraZeneca·interventional·Posted Feb 9, 2021·Updated Apr 24, 2026

In Brief

A Phase 2 clinical trial evaluating Durvalumab, AZD2811, and 3 other interventions for Small-Cell Lung Cancer. Active but no longer recruiting, targeting 31 participants across 12 sites in 4 countries.

Detailed Summary

A Phase II Multicenter, Open-Label, Single Arm Study to Determine the Efficacy, Safety and Tolerability of AZD2811 and Durvalumab Combination as Maintenance Therapy After Induction with Platinum-Based Chemotherapy Combined with Durvalumab, for the First-Line Treatment of Patients with Extensive Stage Small-Cell Lung Cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesPoland, South Korea, Spain, United States
Collaborators--

Timeline

Phase 2Active
2021202220232024202520262027
First PostedFeb 9, 2021
Enrollment StartFeb 23, 2021
Primary CompletionJun 18, 2022
Study CompletionDec 1, 2026
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 5.4 years ago

Interventions

Durvalumabdrug

IV infusions through induction phase. IV infusions through maintenance phase until PD or other discontinuation criteria.

AZD2811drug

IV infusions through maintenance phase until PD or other discontinuation criteria.

Carboplatindrug

IV infusions through induction phase if chosen by Investigator.

Cisplatindrug

IV infusions through induction phase if chosen by Investigator.

Etoposidedrug

IV infusions through induction phase.