At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Multicenter Pilot Study to Evaluate the Effect of EVOO on Lipid Parameters
In Brief
A clinical study evaluating Low polyphenol concentration extra virgin olive oil (EVOO) and High polyphenol concentration extra virgin olive oil (EVOO) for Cardiovascular Diseases. Completed, enrolled 23 participants across 3 sites.
Detailed Summary
The purpose of this multi-center, double-blinded pilot study is to determine if extra virgin olive oil (EVOO) has a positive effect on HDL cholesterol levels and anti-inflammatory markers for subjects diagnosed with cardiovascular disease (CVD) and to determine if the polyphenol concentration is proportional to those effects. Subjects will complete consecutive 28-day periods (with a 14-day washout between) in which they will either consume the low polyphenol concentration EVOO daily or the high polyphenol concentration EVOO. In a double-blinded manner, each subject will be his or her own control with a 14-day washout between study periods. HDL levels and other parameters will be measured after each period of the protocol. The investigators anticipate HDL levels will improve with both olive oils. The investigators expect the high polyphenol concentration EVOO will show a greater effect than the EVOO with a low polyphenol concentration. EVOO with high polyphenol concentration may be a simple method to reduce the risk of secondary CVD events.
Study Details
Timeline
Interventions
Subjects will complete a consecutive 28-day period of consuming low polyphenol concentration EVOO daily.
Subjects will complete a consecutive 28-day period of consuming high polyphenol concentration EVOO daily.