CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 36 enrolled
Drug / intervention
Povidone-Iodine pleural irrigationdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04761133
NCT04761133Phase 1Completed
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Antiseptic Pleural Irrigation for Patients With Pleural Infection

Alexandria University·interventional·Posted Feb 18, 2021·Updated Aug 31, 2022

In Brief

A Phase 1 clinical trial evaluating Povidone-Iodine pleural irrigation for Pleural Infection. Completed, enrolled 36 participants across 1 site.

Detailed Summary

The antiseptic povidone-iodine can safely be instilled into the pleural for the purpose of pleurodesis. Pleural irrigation with antiseptics is used in adults with open drainage for chronic empyema and has been described in the acute management of paediatric pleural infection. This study will investigate the safety and usefulness of povidone-iodine pleural irrigation in 15 eligible patients recruited to the Pleural Infection Cohort Study (PICS) with acute pleural infection. A matched control group will be used and will be composed of 15 patients previously recruited to PICS without receiving povidone-iodine pleural irrigation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPleural Infection
CountriesEgypt
Collaborators--

Timeline

Phase 1CompletedFinished
202120222023202420252026
First PostedFeb 18, 2021
Enrollment StartMar 4, 2021
Primary CompletionJul 31, 2021
Study CompletionAug 15, 2021
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 5.4 years ago

Interventions

Povidone-Iodine pleural irrigationdrug

Irrigation of the infected pleural cavity with an antiseptic solution to reduce microbial load