CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 80 enrolled
Drug / intervention
DESFLURANE AND SEVOFLURANEdrug
Likely dose
Not stated in record
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Search/NCT04771962
NCT04771962Phase 2Completed

Comparing the Efficacy Between Desflurane and Sevoflurane in Miantainance of Spontaneous General Anaesthesia Using Ambu Aura Gain in Paediatrics Patients

Universiti Sains Malaysia·interventional·Posted Feb 25, 2021·Updated Sep 28, 2023

In Brief

A Phase 2 clinical trial evaluating DESFLURANE AND SEVOFLURANE for Paediatrics and General Anaesthesia. Completed, enrolled 80 participants across 1 site.

Detailed Summary

Desflurane and Sevoflurane are one of the modern inhalational anaesthetic agents currently in use in anaesthetic practice. The properties of desflurane that has low blood gas solubility coefficient of 0.47 compared to sevoflurane (0.68) made it more advantageous when used with supraglottic airway in maintaining general anaesthesia in paediatrics . It ensures rapid onset and offset of anaesthesia. Rapid recovery profiles especially among pediatric populations is to ensure less complications associated with prolonged recovery of anaesthesia upon emergence from anaesthesia. Nevertherless, desflurane has its drawback which is it can cause airway irritability related to its pungency. Hence, it is not used as an induction anaesthetic agent in paediatrics. This study was done to evaluate the effectiveness of desflurane in comparison to sevoflurane in maintaining spontaneous general anaesthesia in paediatrics population using Ambu AuraGain .

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesMalaysia
Collaborators--

Timeline

Phase 2CompletedFinished
2020202120222023202420252026
First PostedFeb 25, 2021
Enrollment StartJan 1, 2020
Primary CompletionDec 15, 2021
Study CompletionDec 31, 2021
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 5.4 years ago

Interventions

DESFLURANE AND SEVOFLURANEdrug

COMPARING THE EFFICACY IN MAINTAINANCE OF SPONTANEOUS GENERAL ANAESTHESIA USING AMBU AURA GAIN IN PEDIATRIC PATIENTS