At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula
In Brief
A clinical study evaluating Recommendation for high flow nasal cannula oxygen therapy order set and Provider choice standard care order set for Intubation and Cardiovascular Surgical Procedure. Completed, enrolled 3,568 participants across 1 site.
Detailed Summary
The iCAN trial is a pragmatic randomized controlled trial that aims to test the hypothesis that HFNC versus usual care oxygenation strategies applied immediately after initial extubation after cardiac surgery decreases the all-cause 48-hour reintubation rate (extubation failure within 48 hours of initial extubation).
Study Details
Timeline
Interventions
Participants will be assigned post extubation physician order set which recommends the administration of oxygen therapy via HFNC. HFNC is a heated and humidified system that allows prescribed fraction of inspired oxygen (FIO2) levels to be delivered at very high flow rates.
Participants will receive order set with provider choice of standard care therapy.