CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 13 enrolled
Drug / intervention
Levothyroxine +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04782856
NCT04782856Phase 2Completed
CompareCT.gov

Energy Metabolism in Thyroidectomized Patients

Virginia Commonwealth University·interventional·Posted Mar 4, 2021·Updated Jun 14, 2024

In Brief

A Phase 2 clinical trial evaluating Levothyroxine, Liothyronine, and 1 other intervention for Thyroid Goiter and 2 related conditions. Completed, enrolled 13 participants across 1 site.

Detailed Summary

The purpose of this research study is to measure the changes in energy metabolism (how the body burns energy), cardiovascular function (heart function), and lipid metabolism (cholesterol break down and building) before and after thyroidectomy (surgical removal of thyroid gland) in response to two approved therapies for hypothyroidism: levothyroxine (LT4) or Liothyronine/levothyroxine (LT3/LT4) combination therapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsThyroid Goiter, Hypothyroidism, Thyroid Cancer
CountriesUnited States
CollaboratorsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Timeline

Phase 2CompletedFinished
202120222023202420252026
First PostedMar 4, 2021
Enrollment StartOct 28, 2020
Primary CompletionApr 19, 2023
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 5.3 years ago

Interventions

Levothyroxinedrug

levothyroxine sodium tablet for oral use

Liothyroninedrug

Liothyronine sodium tablets for oral use treatment of hypothyroidism

Placebodrug

inert sugar tablets for oral use blinding for treatment of hypothyroidism