CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 38 enrolled
Drug / intervention
Fish Oil (DPA+EPA 2:1 ratio) Capsules +1 moredietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04796207
NCT04796207N/ACompleted
CompareCT.gov

Study of Effect of Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Supplementation on Biomarkers of Sub-Concussion Injuries in American Football

University of Arizona·interventional·Posted Mar 12, 2021·Updated May 9, 2025

In Brief

A clinical study evaluating Fish Oil (DPA+EPA 2:1 ratio) Capsules and High Oleic Safflower Oil Capsules for Traumatic Brain Injury (TBI) and Chronic Traumatic Encephalopathy (CTE). Completed, enrolled 38 participants across 1 site.

Detailed Summary

Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football athletes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTraumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2020202120222023202420252026
First PostedMar 12, 2021
Enrollment StartMay 28, 2019
Primary CompletionJan 28, 2020
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 5.3 years ago

Interventions

Fish Oil (DPA+EPA 2:1 ratio) Capsulesdietary

The Treatment Arm intervention consists of providing participants with 3 grams of DHA and EPA (2:1 weight ratio) in capsular form. In order to meet the required 3 grams of DHA and EPA, participants were given 6 capsules to be taken with meals (preferably breakfast, although capsules were provided at lunch when they couldn't be provided at breakfast). Capsules were given 5 times a week during the regular football season.

High Oleic Safflower Oil Capsulesdietary

The Placebo Arm intervention consists of providing participants with 3 grams of high-oleic safflower oil in a 1:1 allocation ratio in capsular form. In order to maintain the "study masking", participants in the Placebo Arm were given 6 capsules (the same as the Treatment Arm) to be taken with meals (preferably breakfast, although capsules were provided at lunch when they couldn't be provided at breakfast). Capsules were given 5 times a week during the regular football season.