CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 200 enrolled
Drug / intervention
Standardized Brazilian Green Propolis Extract +1 moredrug
Likely dose
Standardized Brazilian Green Propolis Extract 900mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04800224
NCT04800224Phase 3Completed

The Use of the Standardized Brazilian Green Propolis Extract (EPP-AF) as an Adjunct Treatment for Hospitalized COVID-19 Patients: A Randomized, Double-blind, Placebo-controlled Trial

D'Or Institute for Research and Education·interventional·Posted Mar 16, 2021·Updated May 13, 2022

In Brief

A Phase 3 clinical trial evaluating Standardized Brazilian Green Propolis Extract and Placebo for Covid19 and Inflammation. Completed, enrolled 200 participants across 1 site.

Detailed Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes challenging immune and inflammatory phenomena. Though various therapeutic possibilities have been tested against coronavirus disease 2019 (COVID-19), the most adequate treatment has not yet been established. Among candidate adjunct treatment options, propolis, produced by honey bees from bioactive plant exudates, has shown potential against viral targets and has demonstrated immunoregulatory properties.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBrazil

Timeline

Phase 3CompletedFinished
20222023202420252026
First PostedMar 16, 2021
Enrollment StartApr 12, 2021
Primary CompletionJul 30, 2021
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 5.3 years ago

Interventions

Standardized Brazilian Green Propolis Extractdrug

900mg/day of Standardized Brazilian Green Propolis Extract for 10 days.

Placebodrug

900mg/day of Placebo for 10 days.