CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 348 enrolled / 348 target
Drug / intervention
Cognitive Behavioral Therapy for Cancer Caregivers (CBT-C) +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04802720
NCT04802720N/AActiveUpdate Overdue (5.4/mo)Completion was 16mo ago

A Randomized Controlled Trial of Emotion Regulation Therapy for Cancer Caregivers: A Mechanism-Targeted Approach to Addressing Caregiver Distress

Memorial Sloan Kettering Cancer Center·interventional·Posted Mar 17, 2021·Updated Jun 10, 2026

In Brief

A clinical study evaluating Cognitive Behavioral Therapy for Cancer Caregivers (CBT-C) and Emotion Regulation Therapy for Cancer Caregivers (ERT-C) for Cancer Patients and Family Caregivers. Active but no longer recruiting, targeting 348 participants across 5 sites.

Signals

Enrollment appears stalled

Detailed Summary

The purpose of this study is to compare two types of therapy for caregivers of cancer patients: Emotion Regulation Therapy for Cancer Caregivers (ERT-C) and Cognitive Behavioral Therapy (CBT-C). The researchers want to see if ERT-C is better than, the same as, or worse than traditional CBT-C at improving caregiver distress. The researchers will look at how the two types of therapy affect caregivers' anxiety, depression, and quality of life. The researchers will also see how ERT-C and CBT-C affect hormone and stress levels in caregivers' saliva samples. In addition, this trial will enroll cancer patients in this study to see how their caregivers' participation in ERT-C or CBT may affect the patients' quality of life, stress, and use of healthcare services. Participants who become bereaved while on study will be given the option to withdraw or remain on study. Assessments for bereaved caregivers will not include the Caregiver Quality of Life Index-Cancer (CQOLC) or the Caregiver Reaction Assessment (CRA).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/AActive
2021202220232024202520262027
First PostedMar 17, 2021
Enrollment StartFeb 26, 2021
Primary CompletionFeb 24, 2025
Study CompletionJan 8, 2027
TodayJul 2, 2026
Enrollment to primary: 4.0 yearsPosted 5.3 years ago

Arms & Interventions

ERT-C: Emotion Regulation Therapy for Cancer Caregiversexperimental

Emotion Regulation Therapy for Cancer Caregivers (ERT-C) is an 8-session intervention that builds upon the foundations of CBT-C and addresses earlier motivational processing components of the caregivers context while targeting earlier and later components of internal distress and resultant maladaptive behavioral coping.

Other: Emotion Regulation Therapy for Cancer Caregivers (ERT-C)
CBT-C: Cognitive Behavioral Therapy for Cancer Caregiversexperimental

Cognitive Behavioral Therapy (CBT-C) is an evidence-based psychotherapeutic approach that is grounded in the cognitive model that purports that a person's emotional, behavioral, and physiological reactions to a situation is based on their appraisal of that situation. The focus of therapy is on changing cognitions and beliefs about a situation and altering automatic behavioral responses evoked by that perception. CBT-C aims to improve emotion regulation by challenging and changing unhelpful cognitions and behaviors and improving personal coping strategies.

Other: Cognitive Behavioral Therapy for Cancer Caregivers (CBT-C)
Training case groupexperimental

Will be assigned to receive ERT-C only and will not complete questionnaires.

Other: Emotion Regulation Therapy for Cancer Caregivers (ERT-C)

Interventions

Cognitive Behavioral Therapy for Cancer Caregivers (CBT-C)other

The sessions are outlined as follow: 1. psychoeducation, goal-setting, and describing the rationale for CBT (Session 1); 2. coping effectiveness training (Session 2); 3. identifying unhelpful cognitions and dysfunctional beliefs (Session 3); 4. challenging and restructuring unhelpful cognitions (Session 4); 5. behavioral activation within the limitations of the caregiving context (Session 5); 6. problem-solving (Session 6); 7. communication strategies and assertiveness training (Session 7); 8. consolidating gains, maintenance, and relapse prevention (Session 8).

Emotion Regulation Therapy for Cancer Caregivers (ERT-C)other

The sessions are outlined as follow: 1. psychoeducation and motivation/dysregulation cue detection within caregiving contexts (Session 1); 2. attention regulation skills training (Sessions 1-2); 3. training in metacognitive skills (Sessions 3-4); 4. exposure to proactive living in the face of risk and loss while applying skills (Sessions 5-7); 5. consolidating gains, taking larger proactive steps, and relapse prevention (Session 8).