At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Investigation in Variability and Repeatability of Corneal Sensation in a Normal Population and Contact Lens Wearers
In Brief
A clinical study evaluating Tactile Esthesiometer Prototype, Liquid Jet Esthesiometer Prototype, and 1 other intervention for Cornea and Sense Loss; Cornea. Completed, enrolled 111 participants across 1 site.
Detailed Summary
The aim is to find out more about how corneal sensory fibres react to different types of stimuli (liquid / tactile / nylon thread) and how this can be consciously perceived by the individual. Is it possible to generate a stimulus that delivers a repeatable and reliable response within a useful stimulus force range which allows an interpretation / evaluation of normal / expected activity of superficial nerve fibres in the cornea? The study group will be divided into three groups of individuals: two groups with different types of contact lenses (CL) and one without CL, as sensitivity changes are thought to occur with CL wear. A very interesting research question is to find out, if such sensitivity differences can be detected with the nature of the stimuli applied in this study.
Study Details
Timeline
Interventions
A round plastic nozzle (1.8mm diameter) used as a stimulus for corneal sensation threshold measurement
Balanced salt solution with a pH value similar to the tear film uesd as a liquid jet stimulus for corneal sensation threshold measurement
A nylon thread (0.12mm diameter) used as a stimulus for corneal sensation threshold measurement