At a glance
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Addiction and Behavior Related to Menthol Cigarette Substitutes
In Brief
A clinical study evaluating Menthol cigarettes substitutes, Usual brand menthol cigarettes and substitutes, and 1 other intervention for Smoking (Tobacco) Addiction. Completed, enrolled 120 participants across 1 site.
Detailed Summary
The goal of the proposed study is to examine the abuse liability and substitutability of plausible menthol cigarette alternatives currently on the market, including menthol filtered little cigars (mFLC), menthol roll-your-own (mRYO) pipe tobacco and cigarette tubes, and non-menthol cigarettes (nmC). In addition, the study will elucidate real-time mechanisms including product characteristics and perceived effects associated with greater substitution.
Study Details
Timeline
Interventions
In Phase 1, participants will complete 4 smoking sessions using a different product each session to examine each product's abuse liability.
In Phase 2, to assess uptake, changes in subjective effects, and use over time, participants will select their preferred study product from Phase 1 and be instructed to completely substitute the product for their usual brand menthol cigarette for one week.
In Phase 3, participants will complete a final in-lab visit to assess the substitutability of their preferred product from Phases 1 and 2, under simulated ban conditions using a progressive ratio task.