At a glance
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Deep Brain Stimulation of the Fornix in Alzheimer's Disease: Investigations Into Clinical and Imaging Biomarkers and Dose Optimization
In Brief
A clinical study evaluating Deep Brain Stimulation for Alzheimer Disease. Completed, enrolled 11 participants across 1 site.
Detailed Summary
Title: Deep Brain Stimulation of the Fornix in Alzheimer's Disease: Investigating clinical and imaging biomarkers and dose optimization Objective: To evaluate the influence of deep brain stimulation in Alzheimer's Disease (AD)on markers of AD pathology in cerebrospinal fluid (CSF) and on neuroimaging with positron emission tomography (PET) and to optimize electrical stimulation parameters. Population size: Twelve (12) patients will be recruited and enrolled in this study. Study design: This is a prospective, open-label trial designed to study the effect of brain stimulation on CSF and brain amyloid pathology in AD. In addition, patients will undergo neuropsychological testing at various stimulation settings to help determine optimal stimulation parameters. Study duration: Patients will complete screening and baseline assessments before undergoing DBS implantation surgery, after which they will be followed-up for 12 months.
Study Details
Timeline
Interventions
Personalized Deep Brain Stimulation of Fornix