At a glance
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TRIPLE-A PILOT: Actively Intercepting ADT-Induced Metabolic Aberrations in Newly Diagnosed Prostate Cancer
In Brief
A clinical study evaluating Best Practice, Dietary Intervention, and 3 other interventions for Localized Prostate Carcinoma and Prostate Adenocarcinoma. Completed, enrolled 20 participants across 1 site.
Detailed Summary
This clinical trial studies the effects of a diet and physical activity intervention on blood measures of lipids and insulin resistance in patients with prostate cancer undergoing radiation therapy (RT) and androgen deprivation therapy (ADT). ADT effectively slows the growth of prostate cancer cells, thereby enhancing the therapeutic effectiveness of RT. Despite the clinical gains, ADT leads to an array of side effects including insulin resistance, abnormal lipid levels, weight gain, increased visceral fat mass coupled with increased muscle wasting, and quality of life deterioration. A diet and physical activity intervention may intercept or prevent the abrupt metabolic and physiologic changes caused by androgen deprivation therapy in prostate cancer patients receiving ADT and RT.
Study Details
Timeline
Interventions
Receive standard lifestyle recommendations
Receive dietary instructions
Complete aerobic and strength/resistance exercises
Ancillary studies
Ancillary studies