CI

At a glance

ClinicalIndex Comparison Record
N/ARecruiting· 416 target
Drug / intervention
Conventional Right hemicolectomy (Non-CME) +1 moreprocedure
Likely dose
Not stated in record
Key inclusion· 4
  • Right-sided colon cancer from caecum to proximal third of transverse colon
  • Tumor stage T2-T4a, any N, or T any N+ with no distant metastasis
  • ASA grade I-III
  • Informed consent required
Key exclusion· 11
  • Age greater than 85 years
  • T1, N0 disease
  • T4b disease
  • BMI greater than 30

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04871399
NCT04871399N/ARecruitingOn TrackUpdated 43mo ago
Long Recruiting

Complete Mesocolic Excision With Central Vascular Ligation in Comparison With Conventional Surgery for the Right Colon Cancer: An Italian Randomized Trial

University of Turin, Italy·interventional·Posted May 4, 2021·Updated Nov 14, 2022

In Brief

A clinical study evaluating Conventional Right hemicolectomy (Non-CME) and Right hemicolectomy with CME+CVL for Colon Cancer. Currently recruiting, targeting 416 participants across 14 sites.

Detailed Summary

An Italian randomized controlled trial parallel-group in patients with a malignant tumor of the right or proximal transverse colon requiring right hemicolectomy.

Study Details

Timeline

N/ARecruiting
2021202220232024202520262027
First PostedMay 4, 2021
Enrollment StartJul 13, 2020
Primary CompletionJan 1, 2027
TodayJul 2, 2026
Enrollment to primary: 6.5 yearsPosted 5.2 years agoPrimary completion in 6 months

Interventions

Conventional Right hemicolectomy (Non-CME)procedure

Transecting the Ileocolic Vein and Artery close to the Superior Mesenteric Vessels without clearing the superior mesenteric vein (SMV) from the adipose tissue. Transecting the Right Colic Vein and Artery and superior right colic vein (when present) peripherally. Transecting the Right branches of the Middle Colic Vein (MCV) and the Middle Colic Artery (MCA) peripherally, without clearing the main trunk of the MCV and the MCA. The Right Gastroepiploic Vein and artery are never transacted.

Right hemicolectomy with CME+CVLprocedure

Separation of the visceral fascia from the parietal fascia by sharp dissection leaving intact mesocolon coverage. Transecting the supplying vessels at their origin from the main vessels, particularly: * The Ileocolic Vessels, The Right Colic Vessels,The superior right colic vein (when present), The Right branches of the Middle Colic Vein and of the Middle Colic Artery * The MCV and MCA at their origin in case of cancer of the hepatic flexure or of the proximal third of the transverse colon, as well as The Right Gastroepiploic Vessels at their origin from the gastrocolic trunk of Henle (GCTH) and the gastroduodenal artery. The SMV should be cleared from all adipose tissue all along its anterior surface until its intrapancreatic entrance.