CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 20 enrolled
Drug / intervention
Vancomycin +1 moredrug
Likely dose
Vancomycin 1gfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04872400
NCT04872400Phase 4Completed
CompareCT.gov

Acute Application Of Intrawound Antibiotic Powder In Open Extremity Fracture Wounds

University of Colorado, Denver·interventional·Posted May 4, 2021·Updated Mar 6, 2026

In Brief

A Phase 4 clinical trial evaluating Vancomycin and Tobramycin for Fractures, Open and 5 related conditions. Completed, enrolled 20 participants across 2 sites.

Detailed Summary

The purpose of this study is to help determine the best treatment for severe injures like open fracture wounds. Some broken bone injuries can be more likely to get an infection. It is mostly due to the way they were injured. Surgical site infection in the orthopedic surgery population is a big public health issue. Wound infections result in both longer length of hospital stay and total cost of care. This study will be using an antibiotic called Vancomycin or Tobramycin in a powder form.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsFractures, Open, Wounds and Injuries--Infections, Anti-Bacterial Agents, Fractures, Bone, Extremity Fracture Lower, Extremity Fractures Upper
CountriesUnited States
CollaboratorsDenver Health and Hospital Authority

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedMay 4, 2021
Enrollment StartJun 14, 2021
Primary CompletionSep 30, 2023
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 5.2 years ago

Interventions

Vancomycindrug

1 vial of Vancomycin 1g powder applied topically to the open fracture wound injury.

Tobramycindrug

1 vial of Tobramycin 1.2g powder applied topically to the open fracture wound injury.