CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 1,390 enrolled / 1,390 target
Drug / intervention
Screening testing strategy +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04875520
NCT04875520N/ACompletedHigh Momentum (22.5/mo)Completion was 37mo ago

Assessing Testing Strategies for Safe Return to K-12 Schools in an Underserved Population

Washington University School of Medicine·interventional·Posted May 6, 2021·Updated Jun 29, 2026

In Brief

A clinical study evaluating Screening testing strategy and No screening testing strategy for Covid19. Completed, enrolled 1,390 participants across 5 sites.

Signals

Enrolling ahead of pace

Detailed Summary

The primary goal of this study is to determine the most effective SARS-CoV-2 testing strategy for successful return of in-person school in the under-served communities of St. Louis. Regular screening testing has been recommended by the CDC as an additive mitigation strategy for in-person schools in areas of high community transmission. We will compare the effectiveness and acceptance of two different school-based testing strategies among students and school staff (symptomatic testing only versus weekly surveillance testing plus symptomatic testing), measuring school-based SARS-CoV-2 transmission through a cluster randomized trial.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCovid19
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedMay 6, 2021
Enrollment StartMay 7, 2021
Primary CompletionMay 31, 2023
Study CompletionDec 31, 2023
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 5.2 years ago

Arms & Interventions

Weekly Screening testing plus symptomatic testingactive_comparator

Among 16 middle and high schools, 8 will be randomized to offer students and staff weekly SARS-CoV-2 testing. Additionally, these schools will offer testing for symptomatic students, staff, household members in all age groups.

Other: Screening testing strategy
Symptomatic testingactive_comparator

All 16 schools will have testing available for individuals that have symptoms or need a test for other reasons.

Other: No screening testing strategy

Interventions

Screening testing strategyother

The intervention we are evaluating is the use of weekly screening testing among students and staff.

No screening testing strategyother

a group of schools will not receive screening testing.